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Ttnpb

Intervention

1 paper3 findings

PubChemChEBI

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Arthritis Research UK and 8 more
  • Cells1

Outcomes

3

AC-related matrix proteins

upin human cells1

1 study

  1. Ttnpb induces AC-related matrix proteins in human cells.

    “Chondroprogenitors obtained from RAPID-E could generate cartilaginous pellets that expressed AC-related matrix proteins such as Lubricin, Aggrecan, and Collagen II”

    Cellscartilaginous pellets from RAPID-E chondroprogenitors

    Effect of a retinoic acid analogue on BMP-driven pluripotent stem cell chondrogenesis

    Scientific reports1 Feb 2024

Genes related to AC development

upin human cells1

1 study

  1. Ttnpb increases genes related to AC development in human cells.

    “upregulated genes related to AC development in later stages”

    CellsRAPID-E protocol

    Effect of a retinoic acid analogue on BMP-driven pluripotent stem cell chondrogenesis

    Scientific reports1 Feb 2024

Genes related to limb and embryonic skeletal development

upin human cells1

1 study

  1. Ttnpb increases genes related to limb and embryonic skeletal development in human cells.

    “activation of RAR signalling significantly upregulated genes related to limb and embryonic skeletal development in the early stages of the protocol”

    CellsRAPID-E protocol

    Effect of a retinoic acid analogue on BMP-driven pluripotent stem cell chondrogenesis

    Scientific reports1 Feb 2024

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