TRPML1 agonist
1 paper2 findings
- 1 lab in 1 country
- Funders: Ministry of Science and Technology of the People's Republic of China and 1 more
- Humans1
Outcomes
2Testosterone
upin mice1
1 study
Testosterone
upin mice1
TRPML1 agonist increases testosterone in mice.
“efferent ductular injection and systemic TRPML1 agonist administration restored lysosomal function, normalizing testosterone deficiency and associated abnormalities in high-fat diet-induced LOH mice.”
Animalshigh-fat diet-induced late-onset hypogonadism with testosterone deficiency
Targeting dysregulated phago-/auto-lysosomes in Sertoli cells to ameliorate late-onset hypogonadism
Nature aging22 Apr 2024
Lysosomal function
upin mice1
1 study
Lysosomal function
upin mice1
TRPML1 agonist improves lysosomal function in mice.
“efferent ductular injection and systemic TRPML1 agonist administration restored lysosomal function, normalizing testosterone deficiency and associated abnormalities in high-fat diet-induced LOH mice.”
Animalshigh-fat diet-induced late-onset hypogonadism
Targeting dysregulated phago-/auto-lysosomes in Sertoli cells to ameliorate late-onset hypogonadism
Nature aging22 Apr 2024