Total fluid intake

1. Total fluid intake is associated with prevalent advanced-stage chronic kidney disease in humans (log-OR -0.27; 95% CI -0.43 to -0.11).

   “Higher daily total fluid intake, within the ranges studied, was associated with slower eGFR decline and lower odds of prevalent advanced CKD”

   Reviewkidney

   Fluid Intake and Kidney Function: A Systematic Review and Dose-Response Meta-analysis

   American journal of nephrology·16 Oct 2026

More on Prevalent advanced-stage chronic kidney disease

1. Total fluid intake is associated with eGFR decline in humans (β = 0.97 mL/min/1.73 m2/year; 95% CI 0.15–1.79).

   “Higher total fluid intake was linearly associated with slower eGFR decline”

   Reviewkidney

   Fluid Intake and Kidney Function: A Systematic Review and Dose-Response Meta-analysis

   American journal of nephrology·16 Oct 2026