Tol-d

1. Tol-d decreases cytotoxicity in cells.

   “Tol-D greatly reduced the cytotoxicity induced by Aβ42 fibrillogenesis.”

   Cellsinduced by Aβ42 fibrillogenesis

   Tolcapone Derivative (Tol-D) Inhibits Aβ42 Fibrillogenesis and Ameliorates Aβ42-Induced Cytotoxicity and Cognitive Impairment

   ACS chemical neuroscience·11 Feb 2022

1. Tol-d decreases cognitive dysfunction in mice.

   “Tol-D significantly relieved Aβ-induced cognitive dysfunction in mice experiments.”

   AnimalsAβ-induced cognitive dysfunction in mice experiments

   Tolcapone Derivative (Tol-D) Inhibits Aβ42 Fibrillogenesis and Ameliorates Aβ42-Induced Cytotoxicity and Cognitive Impairment

   ACS chemical neuroscience·11 Feb 2022

More on Cognitive dysfunction

1. Tol-d decreases Aβ deposits in worms.

   “Tol-D significantly alleviated Aβ deposits and extended the lifespan of nematodes in transgenic Caenorhabditis elegans models.”

   Model organismsin transgenic Caenorhabditis elegans models

   Tolcapone Derivative (Tol-D) Inhibits Aβ42 Fibrillogenesis and Ameliorates Aβ42-Induced Cytotoxicity and Cognitive Impairment

   ACS chemical neuroscience·11 Feb 2022

1. Tol-d extends lifespan in worms.

   “Tol-D significantly alleviated Aβ deposits and extended the lifespan of nematodes in transgenic Caenorhabditis elegans models.”

   Model organismsin transgenic Caenorhabditis elegans models

   Tolcapone Derivative (Tol-D) Inhibits Aβ42 Fibrillogenesis and Ameliorates Aβ42-Induced Cytotoxicity and Cognitive Impairment

   ACS chemical neuroscience·11 Feb 2022