TJ0113

InterventionPhase 2

1 paper2 findings

  • 1 lab
  • Cells1

Outcomes

2

THBS1

downin cells1

1 study
  1. TJ0113 decreases THBS1 in cells.

    “This decline directly diminishes histone H3 lysine 18 lactylation (H3K18la), consequently suppressing transcription of the pro-inflammatory gene thrombospondin-1 (THBS1)”

    Cellssenescent cells

    Mitophagy Reprograms Lactate Metabolism to Suppress THBS1 via H3K18la Reduction, Alleviating Intervertebral Disc Degeneration

    Research (Washington, D.C.)5 Nov 2025

More on THBS1

Lactate

downin cells1

1 study
  1. TJ0113 decreases lactate in cells.

    “mitophagy activator TJ0113 drives metabolic reprogramming characterized by substantially reduced lactate production in senescent nucleus pulposus (NP) cells”

    Cellssenescent cells

    Mitophagy Reprograms Lactate Metabolism to Suppress THBS1 via H3K18la Reduction, Alleviating Intervertebral Disc Degeneration

    Research (Washington, D.C.)5 Nov 2025

More on Lactate

Development

Companies
  • PhecdaMedPhase 2sarcopenia, Parkinson's disease

Latest

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