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Tert activator compound

Intervention

1 paper6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: G. Harold and Leila Y. Mathers Foundation and 5 more
  • Animals1

Outcomes

4

CDKN2A expression

downin human cells1downin mice1

1 study

  1. Tert activator compound decreases CDKN2A expression in mice.

    “silences p16INK4a expression via upregulation of DNMT3B-mediated promoter hypermethylation.”

    Animalsvia upregulation of DNMT3B-mediated promoter hypermethylation

    TERT activation targets DNA methylation and multiple aging hallmarks

    Cell21 Jun 2024

  2. Tert activator compound decreases CDKN2A expression in human cells.

    “silences p16INK4a expression via upregulation of DNMT3B-mediated promoter hypermethylation.”

    Cellsvia upregulation of DNMT3B-mediated promoter hypermethylationprimary human cells

    TERT activation targets DNA methylation and multiple aging hallmarks

    Cell21 Jun 2024

More on CDKN2A expression

Cellular senescence

downin human cells1downin mice1

1 study

  1. Tert activator compound decreases cellular senescence in mice.

    “TAC-induced elevation of TERT levels promotes telomere synthesis, blunts tissue aging hallmarks with reduced cellular senescence and inflammatory cytokines”

    Animals

    TERT activation targets DNA methylation and multiple aging hallmarks

    Cell21 Jun 2024

  2. Tert activator compound decreases cellular senescence in human cells.

    “TAC-induced elevation of TERT levels promotes telomere synthesis, blunts tissue aging hallmarks with reduced cellular senescence and inflammatory cytokines”

    Cellsprimary human cells

    TERT activation targets DNA methylation and multiple aging hallmarks

    Cell21 Jun 2024

More on Cellular senescence

Cognitive function

upin mice1

1 study

  1. Tert activator compound improves cognitive function in mice.

    “TAC alleviates neuroinflammation, increases neurotrophic factors, stimulates adult neurogenesis, and preserves cognitive function”

    Animalsbrain

    TERT activation targets DNA methylation and multiple aging hallmarks

    Cell21 Jun 2024

Neuroinflammation

downin mice1

1 study

  1. Tert activator compound decreases neuroinflammation in mice.

    “In the brain, TAC alleviates neuroinflammation”

    Animalsbrain

    TERT activation targets DNA methylation and multiple aging hallmarks

    Cell21 Jun 2024

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