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Syngeneic bone marrow transplantation

Intervention

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: National Institute of Diabetes and Digestive and Kidney Diseases
  • Animals2

Outcomes

2

Lifespan

upin mice2+34% mean life span

2 studies

  1. Syngeneic bone marrow transplantation extends lifespan in mice (+34% mean life span).

    “mean life span increased by 34% with syngeneic transplantation in line C57BL/6 EGFP+”

    Reviewin previous studies in line C57BL/6 EGFP+

    Comparative analysis of syngeneic and allogeneic transplantation without irradiation of the EGFP+ mice bone marrow cells with microspectral fluorescence method

    Biofizika1 Jan 2014

  2. Syngeneic bone marrow transplantation extends lifespan in mice (approximately three-fold).

    “Life span in BMT-treated animals was increased approximately three-fold, approaching that seen in normal mice after BMT.”

    Animalsmurine MPS VII (gusmps/gusmps)1 and 2 years

    Increased life span and correction of metabolic defects in murine mucopolysaccharidosis type VII after syngeneic bone marrow transplantation

    Blood1 Dec 1991

Lysosomal storage

downin mice1

1 study

  1. Syngeneic bone marrow transplantation decreases lysosomal storage in mice.

    “Spleen, liver, cornea, and glomerular mesangial cells showed essentially complete correction at all radiation doses.”

    Animalsmurine MPS VII (gusmps/gusmps)

    Increased life span and correction of metabolic defects in murine mucopolysaccharidosis type VII after syngeneic bone marrow transplantation

    Blood1 Dec 1991

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