GUSB

4 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

1 lab

Humans1
Animals2
In silico1

Associations

3

Fasting serum insulin

downin humans1

1 study

GUSB is associated with fasting serum insulin in humans (β = -2.37, p = 0.030).
“lower fasting serum insulin (β = -2.37, p = 0.030)”
Humansminor allele of exonic SNP rs9530serumfemalesn = 214
Genetic Variation in GUSB Is Associated with Circulating ß-Glucuronidase and Metabolic Traits in Hispanic Postmenopausal Women
ADA Scientific Sessions 2026 abstract5 Jun 2026

More on Fasting serum insulin

Fasting plasma glucose

downin humans1

1 study

GUSB is associated with fasting plasma glucose in humans (β = -13.15, p = 0.042).
“The same allele was also associated with lower fasting plasma glucose (β = -13.15, p = 0.042)”
Humansminor allele of exonic SNP rs9530plasmafemalesn = 214
Genetic Variation in GUSB Is Associated with Circulating ß-Glucuronidase and Metabolic Traits in Hispanic Postmenopausal Women
ADA Scientific Sessions 2026 abstract5 Jun 2026

More on Fasting plasma glucose

Beta-glucuronidase

downin humans1

1 study

GUSB is associated with beta-glucuronidase in humans (β = -0.30, p = 0.0058).
“The minor allele of an exonic GUSB SNP (rs9530) was associated with lower serum β-glucuronidase (β = -0.30, p = 0.0058)”
Humansminor allele of exonic SNP rs9530serumfemalesn = 214
Genetic Variation in GUSB Is Associated with Circulating ß-Glucuronidase and Metabolic Traits in Hispanic Postmenopausal Women
ADA Scientific Sessions 2026 abstract5 Jun 2026

More on Beta-glucuronidase

Latest

2 in 12 months

ADA Scientific Sessions 2026 Abstract6 Jun

Genetic Variation in GUSB Is Associated with Circulating ß-Glucuronidase and Metabolic Traits in Hispanic Postmenopausal Women

Genetic association study of 214 peopleMechanisms

Aging Brain30 Dec

Evaluation of candidate RT-qPCR reference genes in the aging African turquoise killifish brain

Experiments in killifishAI & data

AAIC 2025 Abstract24 Dec

Heterozygosity of lysosomal enzyme genes and Alzheimer's disease

Experiments in miceLysosome

Medicine25 Oct

Machine learning reveal shared diagnostic biomarkers and convergent pathways in age-related hearing loss and sarcopenia

Computational studyAge-related hearing loss