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SV40

Intervention

3 papers1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: National Cancer Institute
  • Cells3

Outcomes

1

Cellular senescence

downin human cells1

1 study

  1. SV40 decreases cellular senescence in human cells (>10 passages).

    “six other human cell clones obtained after transfection with DNA from nondefective mutants or wild-type virus were still growing well at more than 10 passages beyond their expected life span.”

    Cellstransfection with DNA from nondefective mutants or wild-type SV40human cells

    The ability of large T antigen to complex with p53 is necessary for the increased life span and partial transformation of human cells by simian virus 40

    Journal of virology1 Dec 1991

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