Substance P

Substance P has been studied in 2 papers since 2023: none in people yet, 1 in animals, 1 in cells. The research so far is in animals and cells. The newest paper, Nov 22, 2023: “Preconditioning with Substance P Restores Therapeutic Efficacy of Aged ADSC by Elevating TNFR2 and Paracrine Potential”.

2 papers study it24 more mention it2 findingsUpdated Nov 22, 2023

PubChem ChEBI MeSH

1 lab in 1 country

Funders: Government of the Republic of Korea and 1 more

Animals1
Cells1

What did studies of Substance P find?

2

Studies of Substance P measured 2 outcomes; the most studied are TNFRSF1B (1 study) and cell viability (1).

TNFRSF1B

upin cells1

1 study

Substance P increases TNFRSF1B in cells.
“restored TNFR2 expression and paracrine potential, similar to ADSC-Y under inflammatory conditions”
Cellsunder inflammatory conditions (TNF-α exposure)24 h
Preconditioning with Substance P Restores Therapeutic Efficacy of Aged ADSC by Elevating TNFR2 and Paracrine Potential
BiologyNov 22, 2023

More on TNFRSF1B

Cell viability

upin cells1

1 study

Substance P increases cell viability in cells.
“preconditioning with SP significantly enhanced the viability of ADSCs-E”
Cellsunder inflammatory conditions (TNF-α exposure)24 h
Preconditioning with Substance P Restores Therapeutic Efficacy of Aged ADSC by Elevating TNFR2 and Paracrine Potential
BiologyNov 22, 2023

More on Cell viability

Latest

7 papers in 12 months

Drug SafetyOct 14

Reassessing the Neoplasm Signal with Fezolinetant: Regulatory Inference, Mechanistic Plausibility, and the Case for Proactive Pharmacovigilance

Trial in peopleFezolinetant

Aging BrainOct 12

The DentoNeural Axis: A Piezo channel-mediated mechanosensory pathway linking tooth loss to cognitive decline

ReviewMechanisms

bioRxivJul 27

Sensory Neuropeptides Dictate Sex-Specific Synovial Immunity and Cartilage Degeneration in Aging Mice

Preprint: experiments in miceBones and joints

Frontiers in Drug DiscoveryJun 11

Role of Angiotensin-Converting Enzyme in Cognitive Aging: Evidence from Preclinical and Clinical Studies

ReviewInterventions

Cancer LettersApr 16

The paracrine TAC1-TACR1 signaling promotes endothelial senescence and metastatic progression in neuroblastoma

Study in peopleInterventions

Osteoarthritis and CartilageMar 22

Raloxifene injections normalize age-related mechanical sensitization in female and male mice and augment intervertebral disc structure in old female mice

Experiments in miceInterventions

PreprintJan 1

Bidirectional Brain–Skin Signalling in Skin Health, Pigmentation and Ageing

Preprint: study protocolSkin

ENDO 2025 AbstractOct 23

MON-745 The Impact Of Elinzanetant Treatment On Bone Health And Body Composition In Postmenopausal Women

Randomized trial in peopleBones and joints

BiologyDec 22

Preconditioning with Substance P Restores Therapeutic Efficacy of Aged ADSC by Elevating TNFR2 and Paracrine Potential

Experiments in cellsInterventions

Experimental GerontologyOct 29

Age-dependent down-regulation of orexin receptors in trigeminal nucleus caudalis correlated with attenuation of orexinergic analgesia in rats

Experiments in ratsMechanisms