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Subsequent pregnancy

Exposure

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Humans1

Associations

2

DunedinPACE

upin humans1

1 study

  1. Subsequent pregnancy is associated with DunedinPACE in humans (Interaction b = 0.20; SE = .07).

    “particularly for DunedinPACE, where a significant interaction (b = 0.20, SE = .07, P =.006) suggested that subsequent pregnancy disrupted the slowed pace of aging observed postpartum.”

    HumansTime-by-late subsequent pregnancy status interactionsalivaLater postpartum periodfemales

    Maternal Biological Aging in Mid to Late Pregnancy and across Four Years Postpartum: Evidence for Postpartum Recovery and Disruption by Subsequent Pregnancy

    medRxiv1 Jul 2025Preprint

More on DunedinPACE

Absolute telomere length

downin humans1

1 study

  1. Subsequent pregnancy is associated with absolute telomere length in humans (b = −0.78; SE = .36).

    “A subsequent pregnancy in the later postpartum period was independently associated with shorter telomere length (b = −0.78, SE = .36, P =.032)”

    HumansSubsequent pregnancysalivaLater postpartum periodfemales

    Maternal Biological Aging in Mid to Late Pregnancy and across Four Years Postpartum: Evidence for Postpartum Recovery and Disruption by Subsequent Pregnancy

    medRxiv1 Jul 2025Preprint

More on Absolute telomere length

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