Structural disadvantage

1. Structural disadvantage is associated with epigenetic aging and C-reactive protein-related DNA methylation in humans.

   “the association between adolescent structural disadvantage and these outcomes was slightly negative for Black respondents, yet positive for White respondents.”

   HumansInteraction model: slightly negative associations among Black respondents and positive associations among White respondentsvenous bloodn = 3,788

   Structural Disadvantage in Adolescence and Biological Aging in Early Midlife

   JAMA network open·1 May 2026

More on Epigenetic aging and C-reactive protein-related DNA methylation

1. Structural disadvantage is associated with C-reactive protein-related DNA methylation in humans (β 0.07 (95% CI 0.02-0.12)).

   “and greater CRP-related DNAm (β, 0.07 [95% CI, 0.02-0.12]), even after adjusting for self-reported race and family socioeconomic status.”

   HumansAdolescent exposure; adjusted for self-reported race and family socioeconomic statusvenous bloodn = 3,788

   Structural Disadvantage in Adolescence and Biological Aging in Early Midlife

   JAMA network open·1 May 2026

More on C-reactive protein-related DNA methylation

1. Structural disadvantage is associated with DunedinPACE in humans (β 0.08 (95% CI 0.03-0.13)).

   “was associated with accelerated epigenetic aging (GrimAge2: β, 0.35 [95% CI, 0.09-0.61]; DunedinPACE: β, 0.08 [95% CI, 0.03-0.13])”

   HumansAdolescent exposure; adjusted for self-reported race and family socioeconomic statusvenous bloodn = 3,788

   Structural Disadvantage in Adolescence and Biological Aging in Early Midlife

   JAMA network open·1 May 2026

More on DunedinPACE

1. Structural disadvantage is associated with GrimAge2 in humans (β 0.35 (95% CI 0.09-0.61)).

   “exposure to higher vs lower levels of structural disadvantage in adolescence was associated with accelerated epigenetic aging (GrimAge2: β, 0.35 [95% CI, 0.09-0.61];”

   HumansAdolescent exposure; adjusted for self-reported race and family socioeconomic statusvenous bloodn = 3,788

   Structural Disadvantage in Adolescence and Biological Aging in Early Midlife

   JAMA network open·1 May 2026

More on GrimAge2