STL127705

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Animals1

Outcomes

DNA damage

upin A. mexicanum1

1 study

STL127705 increases DNA damage in A. mexicanum.
“Furthermore, we detected a dose-dependent increase in DNA damage, indicated by the γH2AX(Ser139) signal, specifically in cells' nuclei within the regenerated tissues.”
AnimalsDNA repair inhibitionregenerated tissue
Role of non-homologous end joining DNA repair during limb regeneration in Ambystoma mexicanum
Developmental dynamics : an official publication of the American Association of Anatomists19 Mar 2026

Senescent cells

upin A. mexicanum1

1 study

STL127705 increases senescent cells in A. mexicanum.
“we observed a significant increase in the number of senescent cells in the regenerated tissue after KU70/80 inhibition (STL127705) at 32 days post-amputation”
Animalsafter KU70/80 inhibition with STL127705 at 32 days post-amputationregenerated tissue32 days post-amputation
Role of non-homologous end joining DNA repair during limb regeneration in Ambystoma mexicanum
Developmental dynamics : an official publication of the American Association of Anatomists19 Mar 2026

Latest

1 in 12 months

Developmental Dynamics19 Mar

Role of non-homologous end joining DNA repair during limb regeneration in Ambystoma mexicanum

Experiments in axolotlsDNA repair

Paper

STL127705

Outcomes

Latest

Role of non-homologous end joining DNA repair during limb regeneration in Ambystoma mexicanum

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