LIG4

3 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

2 independent labs in 2 countries

Funders: Australian National University and 2 more

Animals2
Cells1

Effects

Radiosensitivity

upin mouse cells1

1 study

LIG4 increases radiosensitivity in mouse cells (four times).
“Radiosensitivity assays revealed that Lig4W447C/W447C cells were four times more radiosensitive than wild-type cells.”
CellsLig4W447C/W447C cells
Promoted Misrejoining of X-ray Radiation-induced DNA Double-Strand Breaks in Novel DNA Ligase IV-Deficient Mouse Cells
Radiation research17 Nov 2025

Stem cell function

downin mice1

1 study

LIG4 impairs stem cell function in mice.
“and severely impairs stem cell function in tissue culture and transplantation”
Animalsin tissue culture and transplantation
DNA repair is limiting for haematopoietic stem cells during ageing
Nature7 Jun 2007

Bone marrow cellularity

downin mice1

1 study

LIG4 decreases bone marrow cellularity in mice.
“causes a progressive loss of haematopoietic stem cells and bone marrow cellularity during ageing”
Animalsin Lig4(Y288C) hypomorphic mutant mice during ageing
DNA repair is limiting for haematopoietic stem cells during ageing
Nature7 Jun 2007

Haematopoietic stem cells

downin mice1

1 study

LIG4 decreases haematopoietic stem cells in mice.
“Diminished DNA double-strand break repair in the Lig4(Y288C) strain causes a progressive loss of haematopoietic stem cells and bone marrow cellularity during ageing”
Animalsin Lig4(Y288C) hypomorphic mutant mice during ageing
DNA repair is limiting for haematopoietic stem cells during ageing
Nature7 Jun 2007