Stemjel

Intervention

1 paper3 findings

  • 1 lab in 1 country
  • Funders: Genentech and 8 more
  • Animals1

Outcomes

3

Osteoarthritis

downin animals1

1 study
  1. Stemjel decreases osteoarthritis.

    “We provide proof of principal that StemJEL preserves the chondrocyte niche and alleviates osteoarthritis.”

    Animalspost-traumatic osteoarthritic jaw and knee joints

    Lgr5-expressing secretory cells form a Wnt inhibitory niche in cartilage critical for chondrocyte identity

    Cell stem cellSep 7, 2023

More on Osteoarthritis

Joint function

upin animals1

1 study
  1. Stemjel improves joint function.

    “Local delivery of StemJEL to post-traumatic osteoarthritic jaw and knee joints in rabbit, rat, and mini-pig models restores cartilage homeostasis, chondrocyte identity, and joint function.”

    Animalspost-traumatic osteoarthritic jaw and knee jointsjoint

    Lgr5-expressing secretory cells form a Wnt inhibitory niche in cartilage critical for chondrocyte identity

    Cell stem cellSep 7, 2023

Cartilage homeostasis

upin animals1

1 study
  1. Stemjel improves cartilage homeostasis.

    “Local delivery of StemJEL to post-traumatic osteoarthritic jaw and knee joints in rabbit, rat, and mini-pig models restores cartilage homeostasis, chondrocyte identity, and joint function.”

    Animalspost-traumatic osteoarthritic jaw and knee jointscartilage

    Lgr5-expressing secretory cells form a Wnt inhibitory niche in cartilage critical for chondrocyte identity

    Cell stem cellSep 7, 2023

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