Sclerostin
2 papers1 finding
- 1 lab in 1 country
- Funders: European Commission and 2 more
- Animals2
Outcomes
1FNDC5
downin mouse cells1
1 study
FNDC5
downin mouse cells1
Sclerostin decreases FNDC5 in mouse cells.
“sclerostin treatment in myoblasts affected their differentiation marker genes and downregulated the irisin precursor Fibronectin domain-containing protein 5 (FNDC5) (p = 0.009).”
CellsC2C12 myoblasts
Journal of translational medicineJun 20, 2026
Funding
1 grant since 2024Biotechnology and Biological Sciences Research Council
Latest
1 in 12 monthsJournal of Translational Medicine
Irisin treatment counteracts bone loss and muscle atrophy in aged mice by reducing sclerostin expression in bone and skeletal muscle
Experiments in miceBone loss
Cell Stem Cell
Lgr5-expressing secretory cells form a Wnt inhibitory niche in cartilage critical for chondrocyte identity
Experiments in rabbitsBones and joints