Stair climbing

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funder: National Institute for Health and Care Research

Humans1

Associations

Mortality

downin humans1RR 0.76

1 study

Stair climbing lowers the risk of mortality in humans (RR 0.76, 95% CI 0.62-0.94).
“stair climbing was also associated with a significant reduction in all-cause mortality (RR 0.76, 95% CI 0.62-0.94, p = 0.01)”
Review
Evaluating the Impact of Stair Climbing on Cardiovascular Risk Reduction: A Systematic Review and Meta-analysis
American journal of cardiovascular drugs : drugs, devices, and other interventions13 Aug 2026

Cardiovascular mortality

downin humans1RR 0.61

1 study

Stair climbing lowers the risk of cardiovascular mortality in humans (RR 0.61, 95% CI 0.48-0.79).
“stair climbing was associated with a significant reduction in cardiovascular mortality (relative risk [RR] 0.61, 95% confidence interval [CI] 0.48-0.79, p = 0.0002)”
Review
Evaluating the Impact of Stair Climbing on Cardiovascular Risk Reduction: A Systematic Review and Meta-analysis
American journal of cardiovascular drugs : drugs, devices, and other interventions13 Aug 2026