Social network

4 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funder: National Institutes of Health

Human trial1
Humans3

Outcomes

HDL and triglycerides

no changein humans1

1 study

Social network has no effect on HDL and triglycerides in humans.
“Increased total network size, diverse ties, or peripheral ties were associated with reduced total cholesterol and LDL, but not HDL or TG”
Human trialincreased network size, diverse ties, or peripheral ties; independent of concurrent changes in MVPAblood6 monthsfemalesn = 199
Expanding social networks through physical activity: implications for cardiometabolic health
Annals of behavioral medicine : a publication of the Society of Behavioral Medicine7 Jan 2026

Associations

Total cholesterol and LDL

downin humans1

1 study

Social network is associated with total cholesterol and LDL in humans.
“Increased total network size, diverse ties, or peripheral ties were associated with reduced total cholesterol and LDL, but not HDL or TG”
Human trialincreased network size, diverse ties, or peripheral ties; independent of concurrent changes in MVPAblood6 monthsfemalesn = 199
Expanding social networks through physical activity: implications for cardiometabolic health
Annals of behavioral medicine : a publication of the Society of Behavioral Medicine7 Jan 2026