Sleep restriction

1. Sleep restriction has no effect on cellular senescence in rats.

   Animalsin aged animals10 consecutive days, every three monthsfemales

   Recurrent Sleep Restriction During Aging Induces Early Recognition Memory Impairment, Neuroinflammation, and Blood–Brain Barrier Dysfunction in Female Wistar Rats · Research Square · 2 Sep 2026 · Preprint

Cellular senescence →

1. Sleep restriction impairs recognition memory in rats.

   Animalsrecurrent sleep restriction10 consecutive days, every three monthsfemales

   Recurrent Sleep Restriction During Aging Induces Early Recognition Memory Impairment, Neuroinflammation, and Blood–Brain Barrier Dysfunction in Female Wistar Rats · Research Square · 2 Sep 2026 · Preprint

1. Sleep restriction increases inflammation in rats.

   Animalsrecurrent sleep restrictionhippocampus10 consecutive days, every three monthsfemales

   Recurrent Sleep Restriction During Aging Induces Early Recognition Memory Impairment, Neuroinflammation, and Blood–Brain Barrier Dysfunction in Female Wistar Rats · Research Square · 2 Sep 2026 · Preprint

Inflammation →

1. Sleep restriction increases blood-brain barrier permeability in rats.

   Animalsrecurrent sleep restrictioncerebral cortex10 consecutive days, every three monthsfemales

   Recurrent Sleep Restriction During Aging Induces Early Recognition Memory Impairment, Neuroinflammation, and Blood–Brain Barrier Dysfunction in Female Wistar Rats · Research Square · 2 Sep 2026 · Preprint

1. Sleep restriction activates DNA damage response in humans.

   “Experimentally restricting sleep in older adults led to acute changes in gene expression indicating increased DNA damage response and senescence related inflammatory activation.”

   Review

   SLEEP: A GEROSCIENCE TARGET · GSA 2024 abstract · 31 Dec 2024

DNA damage response →