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SGP130FC

Intervention

1 paper studies it2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Augusta University and 3 more
  • Cells1

Outcomes

2

Cellular senescence

downin human cells1

1 study

  1. SGP130FC protects against cellular senescence in human cells.

    “while promoting cellular senescence, a phenomenon mitigated by sgp130Fc”

    Cellsin cultured human retinal endothelial cellsretinal endothelial cells

    Blockade of interleukin-6 trans-signaling prevents mitochondrial dysfunction and cellular senescence in retinal endothelial cells

    Experimental eye research

More on Cellular senescence

Oxidative phosphorylation

downin human cells1

1 study

  1. SGP130FC protects against oxidative phosphorylation in human cells.

    “reduced mitochondrial respiration and oxidative phosphorylation, and these effects were counteracted by sgp130Fc”

    Cellsin cultured human retinal endothelial cellsretinal endothelial cells

    Blockade of interleukin-6 trans-signaling prevents mitochondrial dysfunction and cellular senescence in retinal endothelial cells

    Experimental eye research

More on Oxidative phosphorylation

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