Sev-mediated partial reprogramming

1 paper3 findings

1 lab in 1 country

Funders: Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences and 1 more
3 of 3 findings with company ties

Cells1

Outcomes

3

Cellular senescence

downin human cells1

1 study

Sev-mediated partial reprogramming decreases cellular senescence in human cells.
“Transcriptomic profiling showed a reset of senescence-associated programs while retaining mesenchymal identity.”
Cells
Rejuvenation of mesenchymal stromal cells via partial reprogramming enables scalable generation of transcriptionally diverse MSC libraries
Stem cell research & therapy20 Mar 2026

More on Cellular senescence

Telomere length

upin human cells1

1 study

Sev-mediated partial reprogramming increases telomere length in human cells.
“Rejuvenated MSCs (rej-MSCs) demonstrated extended proliferation beyond 100 days, telomere elongation”
Cellsafter SeV clearance
Rejuvenation of mesenchymal stromal cells via partial reprogramming enables scalable generation of transcriptionally diverse MSC libraries
Stem cell research & therapy20 Mar 2026

More on Telomere length

Proliferation

upin human cells1

1 study

Sev-mediated partial reprogramming increases proliferation in human cells (beyond 100 days).
“Rejuvenated MSCs (rej-MSCs) demonstrated extended proliferation beyond 100 days”
Cellsafter SeV clearancebeyond 100 days
Rejuvenation of mesenchymal stromal cells via partial reprogramming enables scalable generation of transcriptionally diverse MSC libraries
Stem cell research & therapy20 Mar 2026

Latest

1 in 12 months

Stem Cell Research & Therapy21 Mar

Rejuvenation of mesenchymal stromal cells via partial reprogramming enables scalable generation of transcriptionally diverse MSC libraries

Experiments in human cellsInterventions