Sepsis

Sepsis has been studied in 6 papers since 2018: 4 observational studies in people, 2 reviews; 4 in the past year. The newest story, Nov 3, 2026: “Severe infection linked to long-term heart rhythm problems”.

Exposure

6 papers study it3 findingsUpdated Aug 4, 2026

1 new paper in 30 daysSee all 6

“Influenza, urinary tract infections, intestinal infections, and sepsis showed independent positive associations with subsequent dementia diagnosis, irrespective of other comorbidities”

Heightened Prevalence of Common Hospital-Treated Infections Preceding Dementia Diagnosis with Accelerated Dementia Onset after InfluenzaThe journal of prevention of Alzheimer's disease2024doi:10.14283/jpad.2024.92

1 of its findings points the other way.

2 independent labs in 2 countries
1 finding against

Funders: National Heart, Lung, and Blood Institute and 7 more

Humans4

What did studies of sepsis find?

Studies of sepsis measured 1 outcome; the most studied are promoter chromatin accessibility (1 study).

Promoter chromatin accessibility

downin mice1upin mice1

1 study

Sepsis decreases promoter chromatin accessibility in mice (persistent after sepsis, with varying DNA methylation).
“persistent closure with varying levels of DNA methylation (Classes 5-7)”
Animalspersistent after sepsis, with varying DNA methylationspleen
Sepsis Induces Age- and Sex-Specific Chromatin Remodeling in Myeloid-Derived Suppressor Cells
bioRxiv : the preprint server for biologyOct 16, 2025Preprint
Sepsis increases promoter chromatin accessibility in mice (age- and sex-dependent).
“age- and sex-dependent sepsis-induced opening (Classes 1-4)”
Animalsage- and sex-dependentspleen
Sepsis Induces Age- and Sex-Specific Chromatin Remodeling in Myeloid-Derived Suppressor Cells
bioRxiv : the preprint server for biologyOct 16, 2025Preprint

More on Promoter chromatin accessibility

What is sepsis linked with?

Studies link sepsis with 1 measure, most often dementia (1 study).

Dementia

upin humans1OR 1.17

1 study

Sepsis is linked with a higher risk of dementia in humans (OR 1.17 (95% CI: 1.01-1.37)).
“Influenza, urinary tract infections, intestinal infections, and sepsis showed independent positive associations with subsequent dementia diagnosis, irrespective of other comorbidities”
Humansn = 58,208
Heightened Prevalence of Common Hospital-Treated Infections Preceding Dementia Diagnosis with Accelerated Dementia Onset after Influenza
The journal of prevention of Alzheimer's diseaseJan 1, 2024

Latest

4 papers in 12 months

BMC MedicineNov 3

Severe infection linked to long-term heart rhythm problems

The adjusted hazard ratio for new heart rhythm disorders was 1.85 after hospital-treated infection compared with no infection, over 14.2 years’ median follow-up.The adjusted hazard ratio for new heart rhythm disorders was 1.85 after hospital-treated infection compared with no infection, over 14.2 years’ median follow-up.

Cohort · 465,374 peoplePopulations