Senescent scattered tubular-like cells
Senescent scattered tubular-like cells has been studied in 1 paper since 2020: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Mar 30, 2020: “Transplanted senescent renal scattered tubular-like cells induce injury in the mouse kidney”.
1 paper studies it5 findingsUpdated
See all 1 papers on senescent scattered tubular-like cells
At a glance
The findings reach mice, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Funder: National Institute of Diabetes and Digestive and Kidney Diseases
- 5 of 5 findings with company ties
- Animals1
What did studies of senescent scattered tubular-like cells find?
5Studies of senescent scattered tubular-like cells measured 5 outcomes, among them IL-6GENEEXPRESSION, CD31+ endothelial cells and kidney fibrosis.
IL-6GENEEXPRESSION
upin mice1
1 study
IL-6GENEEXPRESSION
upin mice1
Senescent scattered tubular-like cells increase IL-6GENEEXPRESSION in mice (compared with control (non-senescent) STCs).
“Senescent kidneys were more fibrotic, with fewer CD31+ endothelial cells, and showed upregulation of IL-6 gene expression.”
Animalscompared with control (non-senescent) STCssenescent (cesium-irradiated porcine STCs)kidney5 × 10^5 cells4 weeks
Transplanted senescent renal scattered tubular-like cells induce injury in the mouse kidney
American journal of physiology. Renal physiology
CD31+ endothelial cells
downin mice1
1 study
CD31+ endothelial cells
downin mice1
Senescent scattered tubular-like cells decrease CD31+ endothelial cells in mice (compared with control (non-senescent) STCs).
“Senescent kidneys were more fibrotic, with fewer CD31+ endothelial cells, and showed upregulation of IL-6 gene expression.”
Animalscompared with control (non-senescent) STCssenescent (cesium-irradiated porcine STCs)kidney5 × 10^5 cells4 weeks
Transplanted senescent renal scattered tubular-like cells induce injury in the mouse kidney
American journal of physiology. Renal physiology
Kidney fibrosis
upin mice1
1 study
Kidney fibrosis
upin mice1
Senescent scattered tubular-like cells increase kidney fibrosis in mice (compared with control (non-senescent) STCs).
“Senescent kidneys were more fibrotic, with fewer CD31+ endothelial cells, and showed upregulation of IL-6 gene expression.”
Animalscompared with control (non-senescent) STCssenescent (cesium-irradiated porcine STCs)kidney5 × 10^5 cells4 weeks
Transplanted senescent renal scattered tubular-like cells induce injury in the mouse kidney
American journal of physiology. Renal physiology
Renal tissue hypoxia
upin mice1
1 study
Renal tissue hypoxia
upin mice1
Senescent scattered tubular-like cells increase renal tissue hypoxia in mice (compared with control (non-senescent) STCs).
“Plasma creatinine and renal tissue hypoxia increased in senescent compared with control cells.”
Animalscompared with control (non-senescent) STCssenescent (cesium-irradiated porcine STCs)kidney5 × 10^5 cells4 weeks
Transplanted senescent renal scattered tubular-like cells induce injury in the mouse kidney
American journal of physiology. Renal physiology
Plasma creatinine
upin mice1
1 study
Plasma creatinine
upin mice1
Senescent scattered tubular-like cells increase plasma creatinine in mice (compared with control (non-senescent) STCs).
“Plasma creatinine and renal tissue hypoxia increased in senescent compared with control cells.”
Animalscompared with control (non-senescent) STCssenescent (cesium-irradiated porcine STCs)5 × 10^5 cells4 weeks
Transplanted senescent renal scattered tubular-like cells induce injury in the mouse kidney
American journal of physiology. Renal physiology