Senescent rabbit adipose-derived mesenchymal stem cells

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Animals1

Outcomes

Intervertebral disc tissue quality

downin O. cuniculus1

1 study

Senescent rabbit adipose-derived mesenchymal stem cells impair intervertebral disc tissue quality in O. cuniculus.
“senescent rADSCs are not only ineffective when used in IVD therapy, but they could also worsen IVD histological features”
Animalsin rabbit model in vivointervertebral disc8 weeks
The regenerative potential of young versus senescent rabbit adipose-derived mesenchymal stem cells and their impact on the treatment of intervertebral disc degeneration
The spine journal : official journal of the North American Spine Society18 Dec 2025

Aggrecan

downin O. cuniculus1

1 study

Senescent rabbit adipose-derived mesenchymal stem cells decrease aggrecan in O. cuniculus.
“senescent rADSCs which had the opposite effect”
Animalsintradiscal delivery of senescent cellsintervertebral disc8 weeks
The regenerative potential of young versus senescent rabbit adipose-derived mesenchymal stem cells and their impact on the treatment of intervertebral disc degeneration
The spine journal : official journal of the North American Spine Society18 Dec 2025

Latest

1 in 12 months

The Spine Journal21 Dec

The regenerative potential of young versus senescent rabbit adipose-derived mesenchymal stem cells and their impact on the treatment of intervertebral disc degeneration

Experiments in rabbitsIntervertebral disc degeneration

Paper

Senescent rabbit adipose-derived mesenchymal stem cells

Outcomes

Latest

The regenerative potential of young versus senescent rabbit adipose-derived mesenchymal stem cells and their impact on the treatment of intervertebral disc degeneration

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