Selenium deficiency

1. Selenium deficiency increases akkermansia muciniphila in mice.

   “dietary Se deficiency accelerated many age-related gut microbial changes in aged telomere-humanized C57BL/6J diabetic mice in a sexually dimorphic manner, with Akkermansia muciniphila showing the greatest enrichment in males”

   Animalstelomere-humanized diabeticmales

   Dietary Selenium Deficiency Accelerates the Onset of Aging-Related Gut Microbial Changes in Aged Telomere-Humanized Mice, With Akkermansia muciniphila Being the Most Prominent and Alleviating Selenium Deficiency-Induced Type 2 Diabetes

   Aging cell·20 Jun 2025

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1. Selenium deficiency activates nutrient sensing in mice.

   “activated signaling pathways linked to longevity-related nutrient sensing”

   Animals

   Selenium Deficiency Is Associated with Pro-longevity Mechanisms

   Cell reports·28 May 2019

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1. Selenium deficiency increases mononucleotides in mice.

   “elevated mononucleotides”

   Animals

   Selenium Deficiency Is Associated with Pro-longevity Mechanisms

   Cell reports·28 May 2019

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1. Selenium deficiency decreases amino acids in mice.

   “Se deficiency reduced amino acid levels”

   Animals

   Selenium Deficiency Is Associated with Pro-longevity Mechanisms

   Cell reports·28 May 2019

More on Amino acids

1. Selenium deficiency decreases selenoprotein expression in mice.

   “Se deficiency led to a drastic decline in selenoprotein expression”

   Animalsentire life

   Selenium Deficiency Is Associated with Pro-longevity Mechanisms

   Cell reports·28 May 2019

More on Selenoprotein expression

1. Selenium deficiency has no effect on lifespan in mice.

   “mice subjected to this dietary regimen for their entire life had normal lifespans”

   Animalsdietary regimenentire life

   Selenium Deficiency Is Associated with Pro-longevity Mechanisms

   Cell reports·28 May 2019