Schisandrol B
Schisandrol B has been studied in 1 paper since 2024: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Aug 6, 2024: “Schisandrol B inhibits calcification of aortic valve by targeting p53 related inflammatory and senescence”.
None of its findings points the other way.
- 1 lab in 1 country
- Funders: National Key Research and Development Program of China and 2 more
- Animals1
What did studies of Schisandrol B find?
5Studies of Schisandrol B measured 5 outcomes; the most studied are inflammation (1 study), cellular senescence (1) and calcification (1).
Inflammation
downin cells1
1 study
Inflammation
downin cells1
Schisandrol B inhibits inflammation in cells.
“thereby promoting p53 ubiquitination and degradation, which further inhibited p53-related inflammatory and senescence response.”
Cells
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Cellular senescence
downin cells1
1 study
Cellular senescence
downin cells1
Schisandrol B inhibits cellular senescence in cells.
“thereby promoting p53 ubiquitination and degradation, which further inhibited p53-related inflammatory and senescence response.”
Cells
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Calcification
downin mice1
1 study
Calcification
downin mice1
Schisandrol B decreases calcification in mice.
“In the murine model, SolB significantly decreased the peak velocity of the aortic valve post-injury and reduced valve fibrosis and calcification.”
Animalspost-wire injuryaortic valve
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Peak velocity
downin mice1
1 study
Peak velocity
downin mice1
Schisandrol B decreases peak velocity in mice.
“In the murine model, SolB significantly decreased the peak velocity of the aortic valve post-injury and reduced valve fibrosis and calcification.”
Animalspost-wire injuryaortic valve
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Osteogenic differentiation
downin human cells1
1 study
Osteogenic differentiation
downin human cells1
Schisandrol B inhibits osteogenic differentiation in human cells.
“SolB inhibited the osteogenic differentiation of hVICs, reversing the increase in calcified nodule formation and osteogenic proteins.”
Cellsosteogenic differentiationaortic valve interstitial cells
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie