Saccharomyces boulardii

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funders: Canadian Institutes of Health Research and 6 more

Model organisms2

Outcomes

Paralysis

downin worms1

1 study

Saccharomyces boulardii decreases paralysis in worms.
“Hanseniaspora opuntiae_W164 and Saccharomyces boulardii_SB delayed beta-amyloid-induced paralysis in C. elegans CL4176.”
Model organismsin C. elegans CL4176
Non-Saccharomyces yeasts contribute to longevity, mitigated protein toxicity, and protection against abiotic stress in Caenorhabditis elegans
Archives of microbiology20 Jan 2026

Locomotive ability

no changein flies1

1 study

Saccharomyces boulardii has no effect on locomotive ability in flies.
“Sb576 supplementation, but not SbWT or spermidine supplementation, of either young flies or old flies for only three days also enhanced STM without affecting locomotive ability.”
Model organismsspermidine-producing yeast strain Sb576three days
Engineered spermidine-secreting Saccharomyces boulardii enhances olfactory memory in Drosophila melanogaster
Frontiers in neuroscience31 Oct 2025

Short-term memory

upin flies1

1 study

Saccharomyces boulardii improves short-term memory in flies.
“food supplemented with live Sb576, but not live wild-type Sb (SbWT) or free spermidine, reduced aging-associated short-term memory (STM) decline.”
Model organismswild-type (w1118) flieslive spermidine-producing yeast strain Sb57630 days
Engineered spermidine-secreting Saccharomyces boulardii enhances olfactory memory in Drosophila melanogaster
Frontiers in neuroscience31 Oct 2025