Ross procedure

1. Ross procedure is associated with cellular senescence in humans.

   “the density of p16INK4A/non-muscle myosin IIB(+)-VSMCs was significantly greater in the pulmonary autograft compared to the pulmonary artery of BAV patients.”

   Humanspulmonary autograft

   Structural dysregulation of the pulmonary autograft was associated with a greater density of p16INK4A-vascular smooth muscle cells

   Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·Dec 15, 2022

More on Cellular senescence

1. Ross procedure is associated with elastin in humans.

   “Structural dysregulation was evident as elastin content of the medial region was significantly reduced in the pulmonary autograft compared to the pulmonary artery of BAV patients.”

   Humanspulmonary autograft

   Structural dysregulation of the pulmonary autograft was associated with a greater density of p16INK4A-vascular smooth muscle cells

   Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·Dec 15, 2022

More on Elastin

1. Ross procedure is associated with pulmonary autograft diameter in humans (47±4 mm vs 26±1 mm).

   “The diameter of the pulmonary autograft (47±4 mm) of three male patients was significantly greater compared to the pulmonary artery (26±1 mm) excised from bicuspid aortic valve (BAV) patients.”

   Humanspulmonary autograftmales

   Structural dysregulation of the pulmonary autograft was associated with a greater density of p16INK4A-vascular smooth muscle cells

   Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·Dec 15, 2022