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RFXCAS13D

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Korea Basic Science Institute and 6 more
  • Animals1

Outcomes

2

Progeroid phenotypes

upin mice1

1 study

  1. RFXCAS13D improves progeroid phenotypes in mice.

    “LMNAG608G/G608G mice exhibited improved progeroid phenotypes”

    Animalsin LMNAG608G/G608G mice

    Precise progerin targeting using RfxCas13d: A therapeutic avenue for Hutchinson-Gilford progeria syndrome

    Molecular therapy : the journal of the American Society of Gene Therapy14 Jun 2025

Cellular senescence

downin mice1

1 study

  1. RFXCAS13D decreases cellular senescence in mice.

    “effectively restored aberrant gene expression and progerin-induced cellular phenotypes, including senescence, mitochondrial dysfunction, and DNA damage”

    Animalsin cells with HGPS and LMNAG608G/G608G mice

    Precise progerin targeting using RfxCas13d: A therapeutic avenue for Hutchinson-Gilford progeria syndrome

    Molecular therapy : the journal of the American Society of Gene Therapy14 Jun 2025

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