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Recombinant human manf

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Animals1

Outcomes

3

Insulin secretion

upin mice1

1 study

  1. Recombinant human manf improves insulin secretion in mice.

    “administration of human recombinant MANF (hrMANF) (0.7 mg/kg, three times/week) reversed the insulin resistance, improved glucose tolerance and insulin secretion.”

    AnimalsD-galactose-induced aging mouse modelhuman recombinant MANFpancreatic β-cell0.7 mg/kg, three times/week

    Identification and validation of the pivotal role of MANF gene in pancreatic β-cell aging using bioinformatics

    Biochemistry and biophysics reports8 Jul 2025

Glucose tolerance

upin mice1

1 study

  1. Recombinant human manf improves glucose tolerance in mice.

    “administration of human recombinant MANF (hrMANF) (0.7 mg/kg, three times/week) reversed the insulin resistance, improved glucose tolerance and insulin secretion.”

    AnimalsD-galactose-induced aging mouse modelhuman recombinant MANF0.7 mg/kg, three times/week

    Identification and validation of the pivotal role of MANF gene in pancreatic β-cell aging using bioinformatics

    Biochemistry and biophysics reports8 Jul 2025

Insulin resistance

downin mice1

1 study

  1. Recombinant human manf decreases insulin resistance in mice.

    “administration of human recombinant MANF (hrMANF) (0.7 mg/kg, three times/week) reversed the insulin resistance”

    AnimalsD-galactose-induced aging mouse modelhuman recombinant MANF0.7 mg/kg, three times/week

    Identification and validation of the pivotal role of MANF gene in pancreatic β-cell aging using bioinformatics

    Biochemistry and biophysics reports8 Jul 2025

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