ApoE4
Biomarker1 paper
- Humans1
Funding
National Institute on AgingUS$15.2mNational Institute of Neurological Disorders and StrokeUS$818.2kEuropean Research Council€150k19 grants since 2022
Metabolic Regulation of Neural Oscillations in APOE4 Genetic Risk for Late Onset Alzheimer’s Disease
National Institute on AgingUniversity of FloridaUS$422.1k2026–2028
Base Editing of APOE4 for Alzheimer's Disease
National Institute on AgingUniversity of KentuckyUS$712.9k2026–2031
National Institute on AgingStanford UniversityUS$621k2022–2027
Study Susceptibility and Resistance to ApoE4 in Alzheimer's Disease
National Institute on AgingJ. David Gladstone InstitutesUS$879k2022–2027
National Institute on AgingUniversity of California, San FranciscoUS$43k2024–2027
National Institute on AgingBrown UniversityUS$636.4k2026–2031
Brain cPLA2 as a mechanism for neuroinflammation in AD/ADRD with and without APOE4
National Institute on AgingUniversity of Southern CaliforniaUS$787.5k2022–2027
Investigating the combined role of APOE4 and ketogenic diets in Alzheimer's disease
National Institute on AgingIcahn School of Medicine at Mount SinaiUS$708.6k2024–2029
Gene Therapy for APOE4 Homozygous Alzheimer's Disease
National Institute on AgingWeill Medical Coll of Cornell UnivUS$3.3m2026–2028
Gene therapeutic conversion from APOE4 to APOE3 to prevent Alzheimer’s disease
European Research CouncilDeutsches Zentrum fur Neurodegenerative Erkrankungen eV€150k2026–2027
Latest
159APOE4 allele modifies the effect of lifestyle interventions on cognition
Brain MRI predicts conversion to mild cognitive impairment
Adding brain MRI to baseline traits predicted conversion from subjective decline to mild impairment with an AUC of 0.923 at five years.Adding brain MRI to baseline traits predicted conversion from subjective decline to mild impairment with an AUC of 0.923 at five years.
Progressive behavioral and cognitive decline in Drosophila harboring AD- associated APOE4 variants
APOE4 is associated with lower adiposity independent of total energy intake in cognitively normal older adults
APOE4 alters olfactory neurons across age and sex in mice
Whole-cell recordings in adult and aged humanized mice showed that APOE4 modified pyramidal cell and interneuron properties depending on both age and…Whole-cell recordings in adult and aged humanized mice showed that APOE4 modified pyramidal cell and interneuron properties depending on both age and sex.