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Recombinant GDF6

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Humans1

Outcomes

1

Osteoarthritis

downin mice1

1 study

  1. Recombinant GDF6 decreases osteoarthritis in mice.

    “intra-articular injection of miR-155-5p inhibitor or recombinant GDF6 could significantly mitigate the severity of impending OA and lessened the progression of existing OA.”

    Animalsin murine overloading-induced OA models

    The PIEZO1/miR-155-5p/GDF6/SMAD2/3 signaling axis is involved in inducing the occurrence and progression of osteoarthritis under excessive mechanical stress

    Cellular signalling18 Mar 2024

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