Pyrroloquinoline quinone disodium salt
Pyrroloquinoline quinone disodium salt has been studied in 4 papers since 2020: 3 trials in people, 1 review. The newest paper, Jan 1, 2024: “The effects of pyrroloquinoline quinone disodium salt on brain function and physiological processes”.
“Significant improvements were observed on the Cognitrax's cognitive function domain score on "composite memory", "verbal memory", "reaction time", "complex attention", "cognitive flexibility", "executive function", and "motor speed" in the mnemoPQQ® group as compared to the placebo group.”
None of its findings points the other way.
- 2 independent labs in 2 countries
- 3 of 5 findings with company ties
- Human trial3
Studies in people
2 studies gave pyrroloquinoline quinone disodium salt to people and measured what changed.
up: Improves cognitive function
up: Improves verbal memory
Randomized trial20-40 years12 weeks
General population; Midlife adults
Food & function, Mar 6, 2023
up: Improves cognitive function
up: Improves Mini-Mental State Examination-Japanese
Randomized trial58 peopleBoth40 to <80 Y12 weeks
Midlife adults; Older adults; healthy
Journal of the American Nutrition Association, Aug 20, 2021
What did studies of Pyrroloquinoline quinone disodium salt find?
5Studies of Pyrroloquinoline quinone disodium salt measured 5 outcomes; the most studied are cognitive function (3 studies), lipid peroxides (1) and verbal memory (1).
Cognitive function
upin humans3
3 studies
Cognitive function
upin humans3
Pyrroloquinoline quinone disodium salt improves cognitive function in humans.
“In younger adults (aged 20-40 years), PQQ improved cognitive function (cognitive flexibility, processing speed, and execution speed) after 8 weeks.”
Human trial20 mg per day8 weeks
Pyrroloquinoline quinone disodium salt improves brain function in both younger and older adults
Food & function
Pyrroloquinoline quinone disodium salt improves cognitive function in humans (healthy).
“Significant improvements were observed on the Cognitrax's cognitive function domain score on "composite memory", "verbal memory", "reaction time", "complex attention", "cognitive flexibility", "executive function", and "motor speed" in the mnemoPQQ® group as compared to the placebo group.”
Human trialhealthypowder21.5 mg/day12 weeksn = 58
Journal of the American Nutrition Association
Pyrroloquinoline quinone disodium salt improves cognitive function in humans.
“Various improvements have been reported regarding general memory, verbal memory, working memory, and attention.”
Review
The effects of pyrroloquinoline quinone disodium salt on brain function and physiological processes
The journal of medical investigation : JMI
Lipid peroxides
downin humans1
1 study
Lipid peroxides
downin humans1
Pyrroloquinoline quinone disodium salt decreases lipid peroxides in humans.
“PQQ ingestion lowers blood lipid peroxide levels in humans, suggesting antioxidant activity.”
Reviewin humans
The effects of pyrroloquinoline quinone disodium salt on brain function and physiological processes
The journal of medical investigation : JMI
Verbal memory
upin humans1
1 study
Verbal memory
upin humans1
Pyrroloquinoline quinone disodium salt improves verbal memory in humans.
“Only older adults (aged 41-65 years) showed improvements in complex and verbal memory after 12 weeks.”
Human trial20 mg per day12 weeks
Pyrroloquinoline quinone disodium salt improves brain function in both younger and older adults
Food & function
Composite Memory
upin humans1
1 study
Composite Memory
upin humans1
Pyrroloquinoline quinone disodium salt improves composite Memory in humans.
“After 12 weeks, the participants showed improvements in composite memory and verbal memory.”
Human trial20 mg per day12 weeks
Pyrroloquinoline quinone disodium salt improves brain function in both younger and older adults
Food & function
Mini-Mental State Examination-Japanese
upin humans1
1 study
Mini-Mental State Examination-Japanese
upin humans1
Pyrroloquinoline quinone disodium salt improves Mini-Mental State Examination-Japanese in humans (healthy).
“The DECO and the MMSE-J scores were also significantly improved in the mnemoPQQ® group.”
Human trialhealthypowder21.5 mg/day12 weeksn = 58
Journal of the American Nutrition Association