Protein phosphatase 2a activators

Intervention

1 paper2 findings

  • 1 lab in 2 countries
  • Funders: Agence Nationale de la Recherche and 5 more
  • Animals1

Outcomes

2

Cellular senescence

downin mouse cells1

1 study
  1. Protein phosphatase 2a activators decrease cellular senescence in mouse cells.

    “Senomorphic function of PP2A activators was demonstrated in mouse primary neural cells with downregulated Ppp2r2c.”

    Cellsin mouse primary neural cells with downregulated Ppp2r2cbrain

    Protein phosphatase 2A activators reverse age-related behavioral changes by targeting neural cell senescence

    Aging cellJan 16, 2023

More on Cellular senescence

Behavioral phenotype

upin zebrafish1

1 study
  1. Protein phosphatase 2a activators improve behavioral phenotype in zebrafish.

    “drugs activating PP2A reversed age-related behavioral changes”

    Animalsin aging or ppp2r2c mutant zebrafish

    Protein phosphatase 2A activators reverse age-related behavioral changes by targeting neural cell senescence

    Aging cellJan 16, 2023

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