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Proteasome activator

Intervention

3 papers study it4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Fondation pour la Recherche Médicale and 4 more
  • Animals2

Outcomes

3

Spatial learning and memory

upin mice2

2 studies

  1. Proteasome activator improves spatial learning and memory in mice.

    “We then showed acute treatment with a proteasome activator to rescue spatial learning and memory deficits in aged mice.”

    Animalsacute

    Proteasome Augmentation Mitigates Age-Related Cognitive Decline in Mice

    Aging cellFeb 13, 2025

  2. Proteasome activator improves spatial learning and memory in mice.

    “We then showed acute treatment with a proteasome activator to rescue spatial learning and memory deficits in aged mice.”

    Animalsbrainacute

    Altered Proteasome Composition in Aging Brains, Genetic Proteasome Augmentation Mitigates Age-Related Cognitive Declines, and Acute Proteasome Agonist Treatment Rescues Age-Related Cognitive Deficits in Mice

    bioRxiv : the preprint server for biologyOct 20, 2024Preprint

Cognitive function

upin reviews1

1 study

  1. Proteasome activator improves cognitive function.

    “protecting degenerating neurons, restoring cognitive functions, and extending life span of organisms”

    Review

    Proteasome Activators and Ageing: Restoring Proteostasis Using Small Molecules

    Sub-cellular biochemistryJan 1, 2024

Lifespan

upin reviews1

1 study

  1. Proteasome activator extends lifespan.

    “protecting degenerating neurons, restoring cognitive functions, and extending life span of organisms”

    Review

    Proteasome Activators and Ageing: Restoring Proteostasis Using Small Molecules

    Sub-cellular biochemistryJan 1, 2024

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