PSMB5

PSMB5 improves cognitive function in mice.

“PSMB5 overexpression preserved proteasome activity and mitigated age‐ and Aβ‐associated deficits in spatial memory and learning.”

Animalsoverexpression in aged and hAPP-J20 mice

Proteasome Activation as a Therapeutic Strategy to Rescue Cognitive Decline in Aging and Alzheimer’s Disease · AAIC 2025 abstract · 23 Dec 2025