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Prim-o-glucosylcimifugin

Intervention

2 papers3 findings

PubChemChEBIMeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Beijing Nova Program and others
  • Animals2

Outcomes

3

Tendon healing

upin mice1

1 study

  1. Prim-o-glucosylcimifugin improves tendon healing in mice.

    “This approach efficiently promotes tendon healing in diabetic mice with partial-cut-induced tendon injury.”

    Animalsdiabetic mice with partial-cut-induced tendon injurymesoporous silica nanoparticles

    Prim-O-Glucosylcimifugin Repairs Diabetic Tendon Injury by Rescuing Tendon Stem/Progenitor Cell Hypofunction Through AMPK Pathway Activation

    Advanced healthcare materialsJun 11, 2025

Autophagy

upin rat cells1

1 study

  1. Prim-o-glucosylcimifugin induces autophagy in rat cells.

    “Mechanistically, POG protects TSPCs against functional impairment during both passage-induced and natural aging by simultaneously suppressing nuclear factor-κB and decreasing mTOR signaling with the induction of autophagy.”

    Cellspassage-induced and natural aging

    Prim-O-glucosylcimifugin ameliorates aging-impaired endogenous tendon regeneration by rejuvenating senescent tendon stem/progenitor cells

    Bone researchOct 23, 2023

More on Autophagy

Tendon regeneration

upin rats1

1 study

  1. Prim-o-glucosylcimifugin improves tendon regeneration in rats.

    “systematic administration of POG or the local delivery of POG nanoparticles functionally rescued endogenous tendon regeneration and repair in aged rats to levels similar to those of normal animals”

    Animalstendon

    Prim-O-glucosylcimifugin ameliorates aging-impaired endogenous tendon regeneration by rejuvenating senescent tendon stem/progenitor cells

    Bone researchOct 23, 2023

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