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Premature menopause

Exposure

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: National Heart, Lung, and Blood Institute
  • Humans1

Associations

2

Circadian syndrome

upin humans1

1 study

  1. Premature menopause raises the risk of circadian syndrome in humans (roughly 30 % higher).

    “Premature menopause (age <40 years) was associated with a roughly 30 % higher CircS risk.”

    Humansfemales

    Associations of reproductive factors and circadian syndrome in middle-aged and elderly women: A nationwide cross-sectional study from China, the United Kingdom and the United States

    Sleep medicine20 Feb 2025

More on Circadian syndrome

Mortality

upin humans1

1 study

  1. Premature menopause raises the risk of mortality in humans.

    “Women who experience premature menopause (before age 40 years) or early menopause (between ages 40 and 45 years) experience an increased risk of overall mortality”

    Reviewfemales

    Premature menopause or early menopause: long-term health consequences

    Maturitas5 Sep 2009

Funding

1 grant since 2023

National Heart, Lung, and Blood InstituteUS$507k

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