Liver Frailty Index

Biomarker5 papers8 findings

Interventions

Exercise

upin humans1Very low certainty

1 study

Exercise improves Liver Frailty Index in humans (-0.14 (95% CI -0.23 to -0.02)).
Human trial12 weeksn = 43
A 12-week home-based exercise program with nutritional guidance is associated with improved functional capacity in chronic liver disease · Clinical nutrition ESPEN · 29 Aug 2026

Mortality

upin humans1HR 2.67

1 study

Liver Frailty Index predicts mortality in humans (from 0.765 to 0.859).
Humanscirrhosisn = 118
Prognostic value of the liver fragility index to predict hospitalization and mortality in outpatients with cirrhosis · Gastroenterologia y hepatologia · 18 Sep 2026
Liver Frailty Index raises the risk of mortality in humans (HR 2.67, 95% CI 1.30-5.51).
Humanscirrhosiscontinuousn = 118
Prognostic value of the liver fragility index to predict hospitalization and mortality in outpatients with cirrhosis · Gastroenterologia y hepatologia · 18 Sep 2026

Hospitalization

upin humans1HR 1.72

1 study

Liver Frailty Index predicts hospitalization in humans (from 0.665 to 0.719).
Humanscirrhosisn = 118
Prognostic value of the liver fragility index to predict hospitalization and mortality in outpatients with cirrhosis · Gastroenterologia y hepatologia · 18 Sep 2026
Liver Frailty Index raises the risk of hospitalization in humans (HR 1.72, 95% CI 1.10-2.68).
Humanscirrhosiscontinuousn = 118
Prognostic value of the liver fragility index to predict hospitalization and mortality in outpatients with cirrhosis · Gastroenterologia y hepatologia · 18 Sep 2026

Adverse muscle composition

upin humans1

1 study

Adverse muscle composition is associated with Liver Frailty Index in humans.
Humansliver cirrhosis undergoing HCC surveillancen = 150
Prevalence and Significance of Combined Low Muscle Volume and High Muscle Fat in Patients with Child-Pugh A-B Cirrhosis · JHEP reports : innovation in hepatology · 11 Sep 2026

Liver stiffness

upin humans1OR 1.24

1 study