Prediabetes
Prediabetes has been studied in 3 papers since 2025: 3 observational studies in people; 3 in the past year. The newest paper, Jun 5, 2026: “Prediabetes Is Associated with Incident Frailty in Community-Dwelling Older Adults: A Five-Year Time-to-Event Analysis from the Bunkyo Health Study”.
3 papers study it2 findingsUpdated
See all 3 papers on prediabetes
At a glance
The findings reach people, from one lab or study. 2 independent labs in 1 country.
“Prediabetes, defined by either ADA or WHO criteria, was significantly associated with increased CRMM risk.”
None of its findings points the other way.
- 2 independent labs in 1 country
- Humans3
What is prediabetes linked with?
2Studies link prediabetes with 2 measures: frailty and cardio-renal-metabolic multimorbidity.
Frailty
upin humans1HR 1.33
1 study
Frailty
upin humans1HR 1.33
Prediabetes are linked with a higher risk of frailty in humans (compared with normal glucose tolerance; Cox model adjusted for age and sex) (HR 1.33, 95% CI 1.02-1.72).
“PreDM was independently associated with an increased risk of frailty onset compared to NGT (HR 1.33, 95% CI 1.02-1.72)”
Humanscompared with normal glucose tolerance; Cox model adjusted for age and sexOGTT-defined5 yearsn = 1,397
ADA Scientific Sessions 2026 abstract
Cardio-renal-metabolic multimorbidity
upin humans1
1 study
Cardio-renal-metabolic multimorbidity
upin humans1
Prediabetes are linked with a higher risk of cardio-renal-metabolic multimorbidity in humans (defined by ADA or WHO criteria).
“Prediabetes, defined by either ADA or WHO criteria, was significantly associated with increased CRMM risk.”
Humansdefined by ADA or WHO criteriamedian follow-up of 15.3 years
American journal of preventive cardiology