Diabetes mellitus
Diabetes mellitus has been studied in 10 papers since 2018: 9 observational studies in people, 1 review; 5 in the past year. The newest paper, Jul 29, 2026: “Synergistic Interactions of Midlife Multimorbidity on Dementia： A Stratified Analysis by Neuropsychiatric Subtypes”.
10 papers study it9 findingsUpdated
See all 10 papers on diabetes mellitus
At a glance
The findings reach people, from one lab or study. 6 independent labs in 4 countries.
“PhenoAgeAccel increased by 1.66 years (95 % CI: 1.38-1.93), and 8.74 years (95 % CI: 8.25-9.22) in adults with prediabetes and DM, respectively”
None of its findings points the other way.
- 6 independent labs in 4 countries
- Funders: National Natural Science Foundation of China and 7 more
- Humans9
What did studies of diabetes mellitus find?
4Studies of diabetes mellitus measured 4 outcomes, among them Alzheimer's disease, PhenoAgeAccel and chronic conditions or disabilities.
Alzheimer's disease
no changein humans1HR 1.07
1 study
Alzheimer's disease
no changein humans1HR 1.07
Diabetes mellitus showed no clear effect on Alzheimer's disease in humans after adjusting for APOE ε4 mutations (HR 1.07, 95% CI 0.97–1.19, P = 0.177).
“After adjusting for APOE ε4 mutations, there was no statistically significant difference in the risk association between DM and AD (HR = 1.07, 95% CI (0.97-1.19), P = 0.177)”
Reviewafter adjusting for APOE ε4 mutations
Frontiers in endocrinology
PhenoAgeAccel
upin humans1
1 study
PhenoAgeAccel
upin humans1
Diabetes mellitus is linked with higher PhenoAgeAccel in adults with high CRP (>3 mg/L), compared with adults without DM (+8.74 years (95% CI 8.25-9.22)).
“PhenoAgeAccel increased by 1.66 years (95 % CI: 1.38-1.93), and 8.74 years (95 % CI: 8.25-9.22) in adults with prediabetes and DM, respectively”
Humansin adults with high CRP (>3 mg/L), compared with adults without DM
Diabetes & metabolic syndrome
Chronic conditions or disabilities
upin humans1
1 study
Chronic conditions or disabilities
upin humans1
Diabetes mellitus is linked with higher chronic conditions or disabilities in humans (native-born Americans born in the South).
“PWD born in the South were more likely to have developed chronic conditions or disabilities and spent greater proportions of life with these two issues compared to other regions.”
Humansnative-born Americans born in the South
Regional differences in the impact of diabetes on population health in the USA
Journal of epidemiology and community health
Life expectancy
downin humans1
1 study
Life expectancy
downin humans1
Diabetes mellitus is linked with shorter life expectancy in humans (native-born Americans, by birth and current residence region) (5.8-10.8 years less).
“At age 50, persons with diabetes (PWD) were expected to live on average 5.8-10.8 years less than their healthy equivalents across regions.”
Humansnative-born Americans, by birth and current residence regionn = 17,686
Regional differences in the impact of diabetes on population health in the USA
Journal of epidemiology and community health
What is diabetes mellitus linked with?
5Studies link diabetes mellitus with 5 measures, among them frailty, cardiovascular mortality and mortality.
Frailty
upin humans1HR 1.44
1 study
Frailty
upin humans1HR 1.44
Diabetes mellitus is linked with a higher risk of frailty in humans (compared with normal glucose tolerance; Cox model adjusted for age and sex) (HR 1.44, 95% CI 1.07-1.94).
“the risk further increased in DM (HR 1.44, 95% CI 1.07-1.94)”
Humanscompared with normal glucose tolerance; Cox model adjusted for age and sex5 yearsn = 1,397
ADA Scientific Sessions 2026 abstract
Cardiovascular mortality
upin humans1HR 3.57
1 study
Cardiovascular mortality
upin humans1HR 3.57
Diabetes mellitus is linked with a higher risk of cardiovascular mortality in humans (HR 3.57 (2.81-4.54)).
“the multivariable-adjusted HRs (95%CIs) of all-cause and cardiovascular mortality in those with DM, CRP, and ageing acceleration were 3.22 (2.79-3.72), and 3.57 (2.81-4.54), respectively”
Humanscombined with high CRP and biological aging acceleration, compared with adults without DM, low CRP and no acceleration
Diabetes & metabolic syndrome
Mortality
upin humans1HR 3.22
1 study
Mortality
upin humans1HR 3.22
Diabetes mellitus is linked with a higher risk of mortality in humans (HR 3.22 (2.79-3.72)).
“the multivariable-adjusted HRs (95%CIs) of all-cause and cardiovascular mortality in those with DM, CRP, and ageing acceleration were 3.22 (2.79-3.72), and 3.57 (2.81-4.54), respectively”
Humanscombined with high CRP and biological aging acceleration, compared with adults without DM, low CRP and no acceleration
Diabetes & metabolic syndrome
Prostate cancer
downin humans1
1 study
Prostate cancer
downin humans1
Diabetes mellitus is linked with a lower risk of prostate cancer in humans (fully adjusted competing risks analysis) (fully adjusted subhazard ratio 0.63; 95% CI 0.43 to 0.92; P = 0.017).
“Diabetes was associated with a lower prostate cancer risk (fully adjusted subhazard ratio, 0.63; 95% CI, 0.43 to 0.92; P = 0.017).”
Humansfully adjusted competing risks analysis12 yearsmalesn = 3,149
The Journal of clinical endocrinology and metabolism
Intracranial vessel wall lesion burden
upin humans1
1 study
Intracranial vessel wall lesion burden
upin humans1
Diabetes mellitus is associated with intracranial vessel wall lesion burden in humans (linear regression with ICAS burden as outcome, adjusted for age and sex) (b=3.2 for presence of diabetes mellitus (95% CI 0.79–5.72)).
“diabetes mellitus ( b=3.2 for presence of diabetes mellitus; 95% CI, 0.79-5.72)”
Humanslinear regression with ICAS burden as outcome, adjusted for age and sexn = 130
Intracranial Vessel Wall Lesions on 7T MRI (Magnetic Resonance Imaging)
Stroke