Prazosin
- 2 independent labs in 2 countries
- 1 trial, 1 about aging
- Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior and 2 more
- Animals2
Outcomes
5MIR92A
upin rats1
1 study
MIR92A
upin rats1
Prazosin increases MIR92A in rats.
“reversed miR-92a gene expression, as well as Akt, mTOR, and NF-κB protein expressions in the aging hippocampus”
Animalsin aging hippocampushippocampus1 mg/kg4 weeksmalesn = 8
Neuroscience lettersJan 10, 2025
Apoptosis
downin rats1
1 study
Apoptosis
downin rats1
Prazosin decreases apoptosis in rats.
“Treatment with prazosin significantly suppressed apoptosis”
Animalsin aging hippocampushippocampus1 mg/kg4 weeksmalesn = 8
Neuroscience lettersJan 10, 2025
Acrosome damage
no changein rats1
1 study
Acrosome damage
no changein rats1
Prazosin has no effect on acrosome damage in rats.
“Prazosin treatment alleviated the effects of hypertension on sperm concentration and motility but not acrosome damage.”
Animalsin spontaneously hypertensive rats
Scientific reportsNov 20, 2024
Sperm motility
upin rats1
1 study
Sperm motility
upin rats1
Prazosin improves sperm motility in rats.
“Prazosin treatment alleviated the effects of hypertension on sperm concentration and motility but not acrosome damage.”
Animalsin spontaneously hypertensive rats
Scientific reportsNov 20, 2024
Blood pressure
downin rats1
1 study
Blood pressure
downin rats1
Prazosin decreases blood pressure in rats.
“Lower blood pressure was observed either in prazosin or losartan-treated adult or aged SHRs.”
Animalsin spontaneously hypertensive rats
Scientific reportsNov 20, 2024
Trials
1 about aging, of 1About aging
Assessing Trauma-related Links Between Affective and Metabolic Systems
Phase 4Not yet recruiting
Trial sponsors
VA Office of Research and Development
1 trialPhase 470 people