Sperm concentration
1 paper2 findings
- Human trial1
Interventions
2Testosterone undecanoate
downin humans1
1 study
Testosterone undecanoate
downin humans1
Testosterone undecanoate decreases sperm concentration in humans.
“whereas sperm concentration and total number decreased significantly in the TRT group.”
Human trialin obese men with type 2 diabetes mellitus and functional hypogonadism1000 mg/10-12 weeks24 weeksmalesn = 25
Diabetes, obesity & metabolism7 Nov 2024
Semaglutide
upin humans1
1 study
Semaglutide
upin humans1
Semaglutide increases sperm concentration in humans.
“Compared to TRT, the SEMA group had a significantly higher number of morphologically normal sperm, sperm concentration and total number.”
Human trialin obese men with type 2 diabetes mellitus and functional hypogonadism compared to TRT1 mg/week24 weeksmalesn = 25
Diabetes, obesity & metabolism7 Nov 2024
Funding
4 grants since 2023National Institute of Child Health and Human DevelopmentUS$787.5kNational Institute of Diabetes and Digestive and Kidney DiseasesUS$1.4m
Sperm epigenetic diagnostic to inform couples time to pregnancy
National Institute of Child Health and Human DevelopmentRipple BiosciencesUS$306.9k2025–2027
Understanding genomic stability between generations by assessing mutational burdens in single sperms
National Institute of Child Health and Human DevelopmentUniversity of UtahUS$249k2025–2028
Understanding genomic stability between generations by assessing mutational burdens in single sperms
National Institute of Child Health and Human DevelopmentUniversity of UtahUS$57.5k2023–2025
Paternal Contributions to Metabolic Disease in Offspring: Environment, Epigenetics, and Sperm
National Institute of Diabetes and Digestive and Kidney DiseasesJoslin Diabetes CenterUS$695.3k2021–2026