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Porphyromonas gingivalis lipopolysaccharide

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funders: Japan Society for the Promotion of Science and 2 more
  • Animals1

Outcomes

3

Lifespan

downin worms1

1 study

  1. Porphyromonas gingivalis lipopolysaccharide shortens lifespan in worms.

    “stimulation with Porphyromonas gingivalis lipopolysaccharide (P. gingivalis LPS) shortens worms' lifespan”

    Model organismsP. gingivalis LPS stimulation

    Hypoxia inducible factor 1 subunit alpha mediates autophagy disorder of oral lichen planus by regulating lysosomal pathway

    Frontiers in immunology14 Apr 2026

Paracellular permeability

upin human cells1

1 study

  1. Porphyromonas gingivalis lipopolysaccharide increases paracellular permeability in human cells.

    “increased permeability to albumin protein”

    Cellsin LPS-treated senescent cellsgingival epithelium

    Oral infection with Porphyromonas gingivalis augmented gingival epithelial barrier molecules alteration with aging

    Journal of oral biosciences7 Feb 2024

More on Paracellular permeability

Transepithelial electrical resistance

downin human cells1

1 study

  1. Porphyromonas gingivalis lipopolysaccharide decreases transepithelial electrical resistance in human cells.

    “LPS-treated senescent cells exhibited a pronounced reduction in TER”

    Cellsin LPS-treated senescent cellsgingival epithelium

    Oral infection with Porphyromonas gingivalis augmented gingival epithelial barrier molecules alteration with aging

    Journal of oral biosciences7 Feb 2024

More on Transepithelial electrical resistance

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