Polyphyllin i

1. Polyphyllin i inhibits apoptosis in human cells.

   “PPI reduced the expression of cleaved caspase-3, bax, MMP-3, and MMP-13 and promoted the expression of collagen II.”

   CellsIL-1β-induced chondrocytes

   Polyphyllin I Mitigated IL-1β-Induced Chondrocytes Damage through Downregulating TWIST1 Expression

   Current molecular medicine·May 10, 2024

More on Apoptosis

1. Polyphyllin i decreases inflammation in human cells.

   “PPI suppressed apoptosis, senescence, inflammation, and ECM degradation of OA chondrocytes by downregulating the expression of TWIST1.”

   CellsIL-1β-induced chondrocytes

   Polyphyllin I Mitigated IL-1β-Induced Chondrocytes Damage through Downregulating TWIST1 Expression

   Current molecular medicine·May 10, 2024

More on Inflammation

1. Polyphyllin i decreases cellular senescence in human cells.

   “The elevation of cell apoptosis, senescence and expression of IL-6 and TNF-α were suppressed by PPI in a dosedependent manner.”

   CellsIL-1β-induced chondrocytes

   Polyphyllin I Mitigated IL-1β-Induced Chondrocytes Damage through Downregulating TWIST1 Expression

   Current molecular medicine·May 10, 2024

More on Cellular senescence

1. Polyphyllin i improves cell viability in human cells.

   “it dose-dependently elevated the inhibition of cell viability regulated by IL-1β.”

   CellsIL-1β-induced chondrocytes0.25, 0.5, 1 μmol/L

   Polyphyllin I Mitigated IL-1β-Induced Chondrocytes Damage through Downregulating TWIST1 Expression

   Current molecular medicine·May 10, 2024