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Polynucleotides

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: Korea Institute for Advancement of Technology
  • Animals1

Outcomes

4

Collagen synthesis

upin Vertebrata cells1

1 study

  1. Polynucleotides increase collagen synthesis in Vertebrata cells.

    “increasing collagen I and III synthesis and reducing nuclear factor-κB activity”

    Cellsin senescent fibroblasts treated with conditioned media from PN-treated macrophages

    Polynucleotides Enhance Collagen Synthesis via Modulating Phosphoenolpyruvate Carboxykinase 1 in Senescent Macrophages: Experimental Evidence

    International journal of molecular sciences7 Sep 2025

pck1

upin Vertebrata cells1

1 study

  1. Polynucleotides increase pck1 in Vertebrata cells.

    “This led to increased PCK1 expression, which reduced oxidative stress and promoted M2 macrophage polarization”

    Cellsin senescent macrophages

    Polynucleotides Enhance Collagen Synthesis via Modulating Phosphoenolpyruvate Carboxykinase 1 in Senescent Macrophages: Experimental Evidence

    International journal of molecular sciences7 Sep 2025

More on pck1

Skin elasticity

upin animal1

1 study

  1. Polynucleotides improve skin elasticity in animal.

    “significantly improved collagen density and skin elasticity over time”

    Animalsin aged animal models

    Polynucleotides Enhance Collagen Synthesis via Modulating Phosphoenolpyruvate Carboxykinase 1 in Senescent Macrophages: Experimental Evidence

    International journal of molecular sciences7 Sep 2025

Collagen density

upin animal1

1 study

  1. Polynucleotides improve collagen density in animal.

    “significantly improved collagen density and skin elasticity over time”

    Animalsin aged animal models

    Polynucleotides Enhance Collagen Synthesis via Modulating Phosphoenolpyruvate Carboxykinase 1 in Senescent Macrophages: Experimental Evidence

    International journal of molecular sciences7 Sep 2025

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