Planetary health diet index

5 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funders: Agencia Estatal de Investigación and 3 more

Humans5

Outcomes

Intrinsic capacity

upin humans1

1 study

Planetary health diet index improves intrinsic capacity in humans (mean difference 0.46 (95% CI 0.05, 0.86)).
“the mean difference (95 % CI) for the 3rd vs. 1st tertile of PHDI was 0.46 (0.05, 0.86)”
Humans6.25 yearsn = 19,505
Adherence to the planetary health diet and healthy aging: A prospective analysis
Clinical nutrition (Edinburgh, Scotland)29 Dec 2025

Associations

Osteoporosis

downin humans1OR 0.923

1 study

Planetary health diet index lowers the risk of osteoporosis in humans (adjusted OR = 0.923, 95% CI 0.905-0.941).
“higher PHDI scores were independently associated with lower odds of osteoporosis (adjusted OR = 0.923; 95% CI 0.905-0.941; p < 0.001)”
Humansfemalesn = 440
The association between a healthy and sustainable diet based on the planetary health diet index (PHDI) and the odds of postmenopausal osteoporosis
European journal of nutrition19 Aug 2026