pi3k-mTOR inhibitor

Intervention

1 paper1 finding

1 lab in 1 country

Funders: California Institute for Regenerative Medicine and 4 more

Animals1

Outcomes

Reversible metabolic arrest

upin mouse cells1

1 study

pi3k-mTOR inhibitor induces reversible metabolic arrest in mouse cells (11 days).
“Screening the PI3K-mTOR axis, we identified a dual inhibitor that pauses embryonic stem cells reversibly at ambient oxygen and holds intact mouse embryos in arrest for 11 days.”
Cellsat ambient oxygenembryo11 days
Metabolic pause protects donor livers and aids survival in rats
bioRxiv9 Oct 2026Preprint

Latest

1 in 12 months

bioRxiv9 Oct

Metabolic pause protects donor livers and aids survival in rats

A flush combining a metabolic inhibitor with a mitochondrial protectant reduced tissue injury and improved survival after warm storage in rat liver transplants.A flush combining a metabolic inhibitor with a mitochondrial protectant reduced tissue injury and improved survival after warm storage in rat liver transplants.

Preprint: experiments in ratsInterventions

Paper

pi3k-mTOR inhibitor

Outcomes

Latest

Metabolic pause protects donor livers and aids survival in rats

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