1 paper2 findings
Pulmonary fibrosis severity
downin mice1
Pharmacological chaperone-mediated autophagy activation decreases pulmonary fibrosis severity in mice.
“pharmacological CMA activation reduces senescent cell burden in aged mice and disease severity in a pulmonary fibrosis mouse model.”
AnimalsPulmonary fibrosis mouse modellung
Protein recycling decline hinders senescent cell clearance in mice
Nature aging5 Oct 2026
Senescent cell burden
downin mice1
Pharmacological chaperone-mediated autophagy activation decreases senescent cell burden in mice.
“pharmacological CMA activation reduces senescent cell burden in aged mice”
Animals
Protein recycling decline hinders senescent cell clearance in mice
Nature aging5 Oct 2026
In experiments in mice, blocking a protein-recycling pathway in immune cells increased the build-up of senescent cells, which had stopped dividing.In experiments in mice, blocking a protein-recycling pathway in immune cells increased the build-up of senescent cells, which had stopped dividing.