Parishin

1. Parishin increases SIRT1 in mice.

   “concomitant with an increase in SIRT1 expression.”

   Animalsnaturally agedlung

   Parishin Alleviates Pulmonary Fibrosis by Reducing CD38 Levels in Naturally Aging Mice

   Rejuvenation research·24 Oct 2024

More on SIRT1

1. Parishin decreases CD38 in mice.

   “parishin treatment led to a reduction in Cluster of differentiation 38 (CD38) levels”

   Animalsnaturally agedlung

   Parishin Alleviates Pulmonary Fibrosis by Reducing CD38 Levels in Naturally Aging Mice

   Rejuvenation research·24 Oct 2024

More on CD38

1. Parishin decreases DNA damage response in mice.

   “The treatment resulted in decreased pulmonary fibrosis and reduced DNA damage in lung tissue.”

   Animalsnaturally agedlung

   Parishin Alleviates Pulmonary Fibrosis by Reducing CD38 Levels in Naturally Aging Mice

   Rejuvenation research·24 Oct 2024

More on DNA damage response

1. Parishin decreases pulmonary fibrosis in mice.

   “The treatment resulted in decreased pulmonary fibrosis and reduced DNA damage in lung tissue.”

   Animalsnaturally agedlung

   Parishin Alleviates Pulmonary Fibrosis by Reducing CD38 Levels in Naturally Aging Mice

   Rejuvenation research·24 Oct 2024

More on Pulmonary fibrosis

1. Parishin decreases cellular senescence in mouse cells.

   “we treated mouse lung epithelial cells with parishin and observed a reduction in cellular senescence markers”

   Cellsin vitrolung

   Parishin Alleviates Pulmonary Fibrosis by Reducing CD38 Levels in Naturally Aging Mice

   Rejuvenation research·24 Oct 2024

More on Cellular senescence

1. Parishin extends lifespan in yeast.

   “Parishin, which is a phenolic glucoside derived from Gastrodia elata, significantly prolonged yeast lifespan.”

   Reviewcited background

   Parishin alleviates vascular ageing in mice by upregulation of Klotho

   Journal of cellular and molecular medicine·9 Apr 2023

1. Parishin increases KL in mice.

   “Expression of Klotho, a protein of age-related declines, was upregulated by parishin in serum and vascular tissue in naturally aged mice.”

   Animalsnaturally agedvascular tissue

   Parishin alleviates vascular ageing in mice by upregulation of Klotho

   Journal of cellular and molecular medicine·9 Apr 2023

More on KL

1. Parishin decreases vascular ageing in mice.

   “Parishin alleviated HCAEC senescence and general age-related features in vascular tissue in naturally aged mice.”

   Animalsnaturally aged

   Parishin alleviates vascular ageing in mice by upregulation of Klotho

   Journal of cellular and molecular medicine·9 Apr 2023